Human/Mouse/Rat Androgen Receptor (aa 1-21), Synthetic Peptide, Invitrogen
Manufacturer: Invitrogen PEP006
Mouse, Rat, Human Androgen Receptor(residues 1-21) Synthetic Peptide, PEP-006, from Invitrogen.The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy ft.s disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS). PEP-006 is a 22 amino acid (amino acids 1-21) synthetic peptide whose sequence is from the amino terminus of the mouse, rat, and human androgen receptor (AR). The sequence of this peptide is (amino to carboxy terminus): M-E-V-Q-L-G-L-G-R-V-Y-P-R-P-P-S-K-T-Y-R-G-C (The C-terminal cysteine has been added to facilitate conjugation and is not a part of the native mouse, rat or human AR sequence)This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and the AR, catalog &Num; PA1-111B. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.Reconstitute with 0.1 mL of distilled water.
|peptide with no preservative|
|M - E - V - Q - L - G - L - G - R - V - Y - P - R - P - P - S - K - T - Y - R - G - C|
|11835, 24208, 367|
|Human, Mouse, Rat|
|Human, Mouse, Rat|
|-20° C, Avoid Freeze/Thaw Cycles|
|Human/Mouse/Rat Androgen Receptor (aa 1-21)|
|P10275, P15207, P19091|
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