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Human Estrogen Receptor alpha (aa 247-261), Synthetic Peptide, Invitrogen™

Synthetic Peptide

Manufacturer:  Invitrogen PEP013

Catalog No. PEP013


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Description

Description

Estrogen Receptor A (ERa) (residues 247-261) Synthetic Peptide, PEP-013, from Invitrogen.

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. PEP-013 is a 15 amino acid (amino acids 247-261) synthetic peptide whose sequence is from the ER-DNA binding domain of the estrogen receptor a. The sequence of this peptide is (amino to carboxy terminus): E-V-G-M-M-K-G-G-I-R-K-D-R-R-GThis peptide may be used for neutralization and control experiments with the monoclonal antibody that reacts with this product and estrogen receptor a, catalog &Num; MA1-310. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.Reconstitute with 0.1 mL of distilled water.
Specifications

Specifications

Synthetic Peptide
purified
50μg
Control
peptide with no preservative
E - V - G - M - M - K - G - G - I - R - K - D - R - R - G
RUO
No preservative
ESR1
Control
2099
Human
0.5 mg/mL
Lyophilized
Y
Human
-20° C, Avoid Freeze/Thaw Cycles
Human Estrogen Receptor alpha (aa 247-261)
P03372
Peptide
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