Invitrogen™ THNSL2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA557258

Catalog No. PIPA557258

Description

Immunogen sequence: AGYIAQKIGL PIRLVVAVNR NDIIHRTVQQ GDFSLSEAVK STLASAMDIQ VPYNMERVFW LLSGSDSQVT RALMEQFERT QSVNLPKEL Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 84%.

THNSL2 (threonine synthase-like 2), also known as TSH2, is a 484 amino acid protein belonging to the threonine synthase family. Utilizing pyridoxal phosphate as a cofactor, THNSL2 may function as a catabolic phospholyase on gamma and beta phosphorylated substrates. THNSL2 may also degrade O-phospho-threonine to alpha-ketobutyrate, ammonia and phosphate. Existing as four alternatively spliced isoforms, THNSL2 is encoded by a gene mapping to human chromosome 2p11.2. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8 gene defects. An extremely rare recessive genetic disorder, Alstrom syndrome, is related to mutations in the ALMS1 gene.

Specifications

• Antigen: THNSL2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: THNSL2
• Gene Alias: BC051244; FLJ10916; FLJ35504; RGD1309144; secreted osteoclastogenic factor of activated T cells; Secreted osteoclastogenic factor of activated T-cells; SOFAT; THNSL2; threonine synthase like 2; threonine synthase-like 2; threonine synthase-like 2 (bacterial); threonine synthase-like 2 (S. cerevisiae); THS2; TSH2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55258
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q86YJ6
• Gene Symbols: THNSL2
• Immunogen: Recombinant protein corresponding to Human THNSL2. Recombinant protein control fragment (Product #RP-96115).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov