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Thymidylate Synthase Mouse anti-Human, Clone: SPM453, Novus Biologicals™
Mouse Monoclonal Antibody
Supplier: Novus Biologicals NBP2343900.02MG
SDSDocumentsProduct Certifications Promotions
DescriptionThymidylate Synthase Monoclonal specifically detects Thymidylate Synthase in Human samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Flow (Intracellular).
|PBS with 0.05% BSA. with 0.05% Sodium Azide|
|EC 184.108.40.206, HsT422, MGC88736, thymidylate synthase, thymidylate synthetase, TMSTsase, TSase, TSHST422|
|Cancer, Cell Cycle and Replication, DNA Repair, DNA replication Transcription Translation and Splicing|
|Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin)|
|Western Blot 0.25-0.5ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunoprecipitation 0.5-1ug/500ug, Immunohistochemistry-Paraffin 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1.0ug/ml|
|Recombinant human thymidylate synthase|
|Protein A purified|
|It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 220.127.116.11). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.|
|Store at 4C.|
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