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Thymidylate Synthase Mouse anti-Human, Clone: TS106, Novus Biologicals™
Mouse Monoclonal Antibody
$229.00 - $459.00
Specifications
Antigen | Thymidylate Synthase |
---|---|
Clone | TS106 |
Dilution | Western Blot 0.25-0.5ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1ug/ml, SDS-Page |
Applications | Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin) |
Classification | Monoclonal |
Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
NBP234445A
|
Novus Biologicals
NBP2344450.1MG |
0.1 mg |
Each for $459.00
|
|
NBP234445F
|
Novus Biologicals
NBP2344450.02MG |
0.02 mg |
Each for $229.00
|
|
NBP234445B
|
Novus Biologicals
NBP2344450.2MG |
0.2 mg | This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000. | N/A |
Description
Thymidylate Synthase Monoclonal specifically detects Thymidylate Synthase in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.Specifications
Thymidylate Synthase | |
Western Blot 0.25-0.5ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1ug/ml, SDS-Page | |
Monoclonal | |
Purified | |
RUO | |
Human | |
P04818 | |
7298 | |
Recombinant human thymidylate synthase | |
Primary | |
Store at 4C. | |
36 kDa |
TS106 | |
Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin) | |
Unconjugated | |
Mouse | |
Cancer, Cell Cycle and Replication, DNA Repair, DNA replication Transcription Translation and Splicing | |
PBS with 0.05% BSA. with 0.05% Sodium Azide | |
EC 2.1.1.45, HsT422, MGC88736, thymidylate synthase, thymidylate synthetase, TMSTsase, TSase, TSHST422 | |
TYMS | |
IgG1 κ | |
Protein A purified | |
It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas. |
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