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Thymidylate synthase Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 150471AP

Catalog No. 50-172-9930


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Description

Description

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Specifications

Specifications

Thymidylate synthase
0.31 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P04818, P07607, P45352
HsT422, Thymidylate synthase, thymidylate synthetase, TMS, TS, TSase, TYMS
Rabbit
IgG
150 μL
-20°C
Primary
22171, 29261, 7298
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
TYMS
Liquid
TYMS
Thymidylate synthase Fusion Protein Ag7027
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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