Thyroglobulin Antibody (2H11), Alexa Fluor™ 350, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP233070AF350

Catalog No. NP233070A30

Description

Thyroglobulin Monoclonal specifically detects Thyroglobulin in Human, Mouse, Rat samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: Thyroglobulin
• Classification: Monoclonal
• Conjugate: Alexa Fluor 350
• Formulation: 50 mM sodium borate with 0.05% sodium azide
• Gene Symbols: TG
• Immunogen: Human thyroid follicular cells were used as immunogen to generate the antibody.
• Quantity: 0.1 mL
• Gene ID (Entrez): 7038
• Target Species: Human, Mouse, Rat
• Isotype: IgG1 κ

• Applications: Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin)
• Clone: 2H11
• Dilution: Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin
• Gene Alias: AITD3TGN, TDH3, Tg, thyroglobulin
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Primary or Secondary: Primary
• Test Specificity: monoclonal antibody 2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by monoclonal antibody 6E1. Thyroglobulin is a 660kDa dimeric pre-protein with multiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-th
• Content And Storage: Store at 4°C in the dark.