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Thyroid Peroxidase, Mouse anti-Human, DyLight 755, Clone: TPO/1922, Novus Biologicals™
Mouse Monoclonal Antibody
Supplier: Novus Biologicals NBP279923IR
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DescriptionThyroid Peroxidase Monoclonal specifically detects Thyroid Peroxidase in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
|50mM Sodium Borate with 0.05% Sodium Azide|
|Recombinant fragment of human Thyroid Peroxidase (around aa 685-804) (Exact sequence is proprietary) (Uniprot: P07202)|
|Lipid and Metabolism|
|Thyroperoxidase (TPO) is a 933-amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.|
|Store at 4°C in the dark.|
|Immunohistochemistry, Immunohistochemistry (Paraffin)|
|EC 1.11.1, MSA, TDH2A, thyroid microsomal antigen, thyroid peroxidase, thyroperoxidase, TPXEC 184.108.40.206|
|Protein A or G purified|
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