Invitrogen™ TIAM2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553098

Catalog No. PIPA553098

Description

Immunogen sequence: IKESDILSDE DDDHRQTVKQ GSPTKDIEIQ FQRLRISEDP DVHPEAEQQP GPESGEGQKG GEQPKLVRGH FCPIKRKANS TKRDRGTLLK AQIRHQSLDS QSENATIDLN SVL Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 72%.

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA.

Specifications

• Antigen: TIAM2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tiam2
• Gene Alias: 3000002F19Rik; KIAA2016; mKIAA2016; RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1; SIF and TIAM1-like exchange factor; Stef; T cell lymphoma invasion and metastasis 2; T-cell lymphoma invasion and metastasis 2; T-cell lymphoma invasion and metastasis 2; RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1; TIAM2; TIAM-2; T-lymphoma invasion and metastasis-inducing protein 2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26230
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IVF5
• Gene Symbols: Tiam2
• Immunogen: Recombinant protein corresponding to Human TIAM2. Recombinant protein control fragment (Product #RP-90642).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov