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TIGIT Monoclonal Antibody (MBSA43), Functional Grade, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
$128.00 - $432.65
Specifications
Antigen | TIGIT |
---|---|
Clone | MBSA43 |
Concentration | 1 mg/mL |
Applications | Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin) |
Classification | Monoclonal |
Description
Description: The MBSA43 monoclonal antibody reacts with human T cell immunoreceptor with Ig and ITIM domains (TIGIT), which is also known as VSTM3 or WUCAM. This 26 kDa protein is a member of the poliovirus receptor (PVR) family. The expression of TIGIT has been reported on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells, but it is not expressed on B cells or naive CD4+ T cells. TIGIT may be upregulated on naive CD4+ T cells upon activation. TIGIT can interact with certain members of the PVR and PVR-like families, including CD155, and also mediates the interaction of NK and T cells with antigen presenting cells, fibroblasts, and endothelial cells that express PVR and PVR-like proteins. MBSA43 is reported to crossreact with Rhesus macaque. Applications Reported: This MBSA43 antibody has been reported for use in flow cytometric analysis. In a functional assay, MBSA43 enhances IFN gamma secretion following TCR activation. Applications Tested: This MBSA43 antibody has been tested by flow cytometric analysis. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Endotoxin: Less than 0.
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.Specifications
TIGIT | |
1 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with no preservative; pH 7.2 | |
ENSMUSG00000071552; T cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3; Washington University cell adhesion molecule; WUCAM | |
TIGIT | |
Primary | |
4° C | |
TIGIT |
MBSA43 | |
Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin) | |
Functional Grade | |
Mouse | |
Human | |
Q495A1 | |
201633 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.
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