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TLK2 Mouse anti-Human, Clone: OTI2H2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526741

Catalog No. PIMA526741


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Description

Description

TLK2, a member of the Ser/Thr protein kinase family, is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.
Specifications

Specifications

TLK2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q86UE8
Serine/threonine-protein kinase tousled-like 2; HsHPK; PKU-alpha; Tousled-like kinase 2; TLK2
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
11011
Immunohistochemistry (Paraffin)
OTI2H2
Unconjugated
TLK2
Liquid
TLK2
Human recombit protein fragment corresponding to amino acids 1-296 of TLK2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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