TLR2 Mouse, Clone: TLR2/221, Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NBP247747A	Novus Biologicals NBP2477470.1MG	0.1 mg
NBP247747B	Novus Biologicals NBP2477470.2MG	0.2 mg

Description

TLR2 Monoclonal specifically detects TLR2 in Human, Canine, Monkey samples. It is validated for Functional.

Specifications

• Antigen: TLR2
• Concentration: 1.0 mg/mL
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence, CyTOF
• Conjugate: Unconjugated
• Host Species: Mouse
• Research Discipline: Cytokine Research, Immunology, Innate Immunity, Signal Transduction, Toll Like Receptors
• Formulation: PBS with No Preservative
• Gene ID (Entrez): 7097
• Immunogen: Recombinant human TLR2 protein
• Primary or Secondary: Primary
• Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Molecular Weight of Antigen: 90 kDa

• Clone: TLR2/221
• Dilution: Flow Cytometry : 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin : 0.5 - 1.0 ug/ml, Immunofluorescence : 1 - 2 ug/ml, CyTOF-ready
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Human, Canine, Monkey
• Gene Alias: CD282 antigen, TIL4CD282, toll/interleukin 1 receptor-like 4, Toll/interleukin-1 receptor-like protein 4, toll-like receptor 2
• Gene Symbols: TLR2
• Isotype: IgG2a κ
• Purification Method: Protein A or G purified
• Test Specificity: This MAb reacts with human Toll-like receptor 2 (TLR2). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.