Invitrogen™ TLR9 Monoclonal Antibody (5G5), Biotin

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA549116

Catalog No. FERMA549116

Description

The monoclonal antibody 5G5 reacts with RAW macrophages and TLR9 transfected HEK293 cells, and is cross reactive with canine TLR9.

The protein encoded by this gene is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

Specifications

• Antigen: TLR9
• Classification: Monoclonal
• Concentration: 100 μg/mL
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide
• Gene Accession No.: Q9EQU3, Q9NR96
• Gene Symbols: Tlr9
• Immunogen: Purified fusion protein of extracellular domain of human TLR9 (AA 1-815) and human IgGFc.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Inhibition Assays, Western Blot
• Clone: 5G5
• Conjugate: Biotin
• Gene: Tlr9
• Gene Alias: CD289; Tlr9; toll like receptor 9; toll-like receptor 9; UNQ5798/PRO19605
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 54106, 81897
• Content And Storage: 4°C
• Form: Liquid