Dual-kinase inhibitor; inhibits CK2 and ERK8
Manufacturer: Tocris 3675/10
DescriptionDual-kinase inhibitor; inhibits both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50µM for both CK2 and ERK8). Displays selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki values are 0.25, 8.65, 11.90 and 15.25µM for CK2, PIM1, DYRK1a and HIPK2 respectively).
- Chemical Name: 2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)acetic acid
- Formula: C11H9Br4N3O2
- CAS Number: 905105-89-7
- Solubility: Soluble to 25mM in DMSO
- Purity: >98