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TMED10/TMP21 Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
$151.31
Specifications
| Antigen | TMED10/TMP21 |
|---|---|
| Applications | Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Form | Liquid |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-156-9864
|
Bethyl Laboratories, Inc
A305228AT |
20 μL |
Each of 1 for $151.31
|
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Description
The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Orangutan
TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.Specifications
| TMED10/TMP21 | |
| Polyclonal | |
| Liquid | |
| RUO | |
| TBS with 0.1% BSA and 0.09% sodium azide | |
| Transmembrane emp24 domain-containing protein 10 , Transmembrane protein Tmp21 , 21 kDa transmembrane trafficking prote | |
| Between 50 and 100 | |
| Primary | |
| 4° C | |
| TMED10 |
| Western Blot | |
| Unconjugated | |
| Rabbit | |
| Human, Mouse | |
| P49755, Q9D1D4 | |
| 10972, 68581 | |
| IgG | |
| Antigen affinity chromatography | |
| Antibody |
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