TMEM173 Monoclonal Antibody (OTI1A3), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA505016

Catalog No. 50-167-5573

Description

STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.

Specifications

• Antigen: TMEM173
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q86WV6
• Gene Symbols: TMEM173
• Immunogen: Full length human recombit protein of human TMEM173 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI1A3
• Conjugate: Unconjugated
• Gene: TMEM173
• Gene Alias: ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 340061
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid