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TMEM173 Mouse anti-Human, Clone: OTI1G5, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA505018

Catalog No. 50-167-5575


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Description

Description

STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.
Specifications

Specifications

TMEM173
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q86WV6
ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
340061
Flow Cytometry, Western Blot
OTI1G5
Unconjugated
TMEM173
Liquid
TMEM173
Full length human recombit protein of human TMEM173 produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
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