TMEM173 Mouse anti-Human, Clone: OTI2C8, liquid, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene TA505020
DescriptionSTING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Western Blot|
|Full length human recombit protein of human TMEM173 produced in HEK293T cell.|
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