Invitrogen™ TMEM30A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553193

Catalog No. PIPA553193

Description

Immunogen sequence: VKSRDDSQLN GDSSALLNPS KECEPYRRNE DKPIAPCGAI ANSMFNDTLE LFLIGNDSYP IPIALKKKGI AWWTDKNVKF RNPPGGDNLE ERFKGTTKPV NWLKPVYMLD SDPDNNGFI Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 84%.

Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediates the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations. [UniProt].

Specifications

• Antigen: TMEM30A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TMEM30A
• Gene Alias: 2010200I23Rik; AW540225; C6orf67; Cdc50a; cell cycle control protein 50A; cell cycle control protein 50A; LOW QUALITY PROTEIN: cell cycle control protein 50A; Cell cycle control protein 50A-like protein; D9Wsu20e; FLJ10856; P4-ATPase flippase complex beta subunit TMEM30A; TMEM30A; Transmembrane protein 30A
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55754
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NV96
• Gene Symbols: TMEM30A
• Immunogen: Recombinant protein corresponding to Human TMEM30A. Recombinant protein control fragment (Product #RP-90931).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov