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TMEM38B Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 199191AP

Catalog No. 50-173-2603


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Description

Description

TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
Specifications

Specifications

TMEM38B
0.38 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q9NVV0
C9orf87, D4Ertd89e, TMEM38B, transmembrane protein 38B, TRIC B, TRICB
Rabbit
IgG
150 μL
-20°C
Primary
55151
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
TMEM38B
Liquid
TMEM38B
TMEM38B Fusion Protein Ag13835
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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