TMEM59 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Thermo Scientific PA598200
DescriptionProcessing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 50% glycerol and 0.03% Proclin 300; pH 7.4|
|Recombit Human Transmembrane protein 59 protein (59-201AA)|