BioVision Inc TMRE Mitochondrial Membrane Potential Assay Kit (Fluorometric): Convenient method based on the cell-permeable TMRE dye which readily accumulates in the active mitochondria. Includes Protonophores FCCP to validate the assay. 200 assays.
Manufacturer: BioVision Inc K238200
Mitochondria are the powerhouse of the cells and generate energy in the form of ATP. Mitochondria utilize oxidizable substrates to produce a membrane potential in the form of a proton gradient across the mitochondrial inner membrane. Mitochondrial membrane potential is tightly interlinked to many mitochondrial processes, including ATP synthesis, ROS, calcium sequestration and import of proteins into the mitochondrion. Therefore, pharmacological changes in mitochondrial membrane potential are associated with several pathological parameters. BioVision’s TMRE Mitochondrial Membrane Potential Assay Kit uses TMRE (tetramethylrhodamine, ethyl ester) to label active mitochondria. TMRE is a cell-permeable, positively-charged, red-orange dye that readily accumulates in active mitochondria. Protonophores like FCCP and CCCP induces dissipation of mitochondrial membrane thus results in compromised staining. BioVision charges an Ice pack and Insulated Container fee of $25.00 for each order.
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