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TNF alpha Rat anti-Mouse, FITC, Clone: MP6-XT22, Invitrogen™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

Manufacturer:  Invitrogen RM9011

Catalog No. 50-113-8195


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Description

Description

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Specifications

Specifications

TNF alpha
Monoclonal
0.1 mg/mL
PBS with BSA and 0.1% sodium azide
P06804
APC1 protein, TNF superfamily, member 2, TNF, macrophage-derived, TNF, monocyte-derived, TNF-a, cachectin, tumor necrosis factor alpha, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha, TNFA
Rat
IgG1
1 mL
4° C
Primary
21926
Flow Cytometry
MP6-XT22
FITC
Tnf
Liquid
Tnf
Mouse TNF Alpha.
Purified
RUO
Antibody
Monoclonal
Mouse
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