TOB1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 149151AP
14915-1-AP recognizes 38 and 45 kDa bands. The additional 45 kDa band may be due to phosphorylation.This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|P50616, Q61471, Q8R5K6|
|APRO6, PIG49, Protein Tob1, TOB, TOB1, Transducer of erbB 2 1, transducer of ERBB2, 1, TROB, TROB1|
|10140, 170842, 22057|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|TOB1 Fusion Protein Ag6714|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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