Potent PDGFR and VEGFR inhibitor
Manufacturer: Tocris 3909/10
DescriptionPotent ATP-competitive PDGFR and VEGFR inhibitor (Ki = 5 and 6 nM, respectively); inhibits phosphorylation of c-Kit and suppresses the growth of mast cell lines expressing mutant Kit, inducing cell cycle arrest and apoptosis. Also inhibits FGFR1 (Ki = 0.5µM). Effective in vivo.
- Chemical Name: 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide
- Formula: C22H25FN4O2
- CAS Number: 356068-94-5
- Solubility: Soluble to 10mM in DMSO with gentle warming
- Purity: >98