Tocris™ Toceranib

Potent PDGFR and VEGFR inhibitor

Manufacturer: Tocris™ 3909/10

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Catalog No. 39-091-0

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For Research Use Only


    Specifications

    Product Type Toceranib
    Inhibitors Toceranib
    Purity >98
    Molecular Weight 396.46
    Quantity 10mg

    Potent ATP-competitive PDGFR and VEGFR inhibitor (Ki = 5 and 6 nM, respectively); inhibits phosphorylation of c-Kit and suppresses the growth of mast cell lines expressing mutant Kit, inducing cell cycle arrest and apoptosis. Also inhibits FGFR1 (Ki = 0.5µM). Effective in vivo.

    • Chemical Name: 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide
    • Formula: C22H25FN4O2
    • CAS Number: 356068-94-5
    • Solubility: Soluble to 10mM in DMSO with gentle warming
    • Purity: >98

  • Description & Specifications

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