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Tocris Bioscience™ Catestatin
Non-competitive nicotinic cholinergic antagonist
Supplier: Tocris Bioscience™ 2722/1
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Non-competitive nAChR antagonistCatestatin is a non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ∽ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ∽ 200 - 250 nM) and inhibits nicotinic-agonist induced desensitization of catecholamine release. Also stimulates mast cell release of histamine via a separate mechanism.
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