Tocris Bioscience GaTx2
High affinity, selective ClC-2 blocker; inhibits slow-gating
Manufacturer: Tocris Bioscience 4911/100U
DescriptionVery high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4)TR, GABAC, CaCC and KV1.2.
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