Tocris Bioscience™ JKC 363
Potent and selective MC4 receptor antagonist
Manufacturer: Tocris Bioscience™ 3426/500U
DescriptionJKC 363 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 0.5 and 44.9 nM at MC4 and MC3 respectively) that antagonizes the effects of α-MSH. Suppresses thyrotropin-releasing hormone (TRH) release, attenuates food intake and reduces formalin-induced pain in vivo.