Tocris Bioscience Nocistatin (bovine)
Opposes action of nociceptin
Manufacturer: Tocris Bioscience 1118/1
DescriptionAn endogenous peptide derived from the same precursor as nociceptin, which is able to block nociceptin-induced allodynia and hyperalgesia and may play an opposing role in pain transmission. Shown to reverse nociceptin inhibition of glutamate release from rat brain slices; also modulates 5-HT transmission in the mouse neocortex via mechanisms separate from nociceptin/orphanin FQ.
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