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Tocris Bioscience™ ZIP

Cell-permeable inhibitor of atypical PKC isozyme PKMζ

Supplier:  Tocris Bioscience™ 2549/1

Catalog No. 25-491


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Description

Description

ZIP is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

Control Peptide and Biotinylated Peptide also available.

Specifications

Specifications

95%
Store at -20°C
observed_molecular_weight: 1928.4
1 mg
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