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TOLLIP Mouse anti-Human, Clone: OTI2A4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526308

Catalog No. PIMA526308


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Description

Description

Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
Specifications

Specifications

TOLLIP
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9H0E2
IL-1RAcPIP; adapter protein; toll-interacting protein
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
54472
Immunohistochemistry (Paraffin), Western Blot
OTI2A4
Unconjugated
TOLLIP
Liquid
TOLLIP
Full length human recombit protein of TOLLIP produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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