Tocris™ Tolvaptan

Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally active

Manufacturer: Tocris™ 5181/10

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Catalog No. 51-811-0

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For Research Use Only


    Product Type Tolvaptan
    Inhibitors Tolvaptan
    Purity >98
    Molecular Weight 448.94
    Quantity 10mg

    Potent and selective competitive vasopressin V2 receptor antagonist (Ki values are 0.06 and 12.3nM for V2 and V1a receptors respectively). Decreases urine osmolality and increases serum sodium concentrations. Delays the onset of end-stage renal disease in a mouse model of polycystic kidney disease. Exhibits myocardial and renal protective effects in hypertensive heart failure rats. Orally active.

    • Chemical Name: N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
    • Formula: C26H25ClN2O3
    • CAS Number: 150683-30-0
    • Solubility: Soluble to 100mM in DMSO and to 10mM in ethanol
    • Purity: >98

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