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Tocris™ Topiramate

GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV

Manufacturer:  Tocris™ 3620/10

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Catalog No. 36-201-0R

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For Research Use Only



Anticonvulsant. Antagonizes GluR5 kainate receptors (IC50 = 0.46µM), acts as a positive allosteric modulator of GABAA receptor-mediated currents, inhibits Nav channels (IC50 = 48.9µM) and inhibits L-type Ca2+ channels. Also inhibits carbonic anhydrase (CA) (Ki values are 0.1 and 0.2µM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.
  • Chemical Name: 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
  • Formula: C12H21NO8S
  • CAS Number: 97240-79-4
  • Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
  • Purity: >99
Description & Specifications


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