GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV
Manufacturer: Tocris 3620/10
DescriptionAnticonvulsant. Antagonizes GluR5 kainate receptors (IC50 = 0.46µM), acts as a positive allosteric modulator of GABAA receptor-mediated currents, inhibits Nav channels (IC50 = 48.9µM) and inhibits L-type Ca2+ channels. Also inhibits carbonic anhydrase (CA) (Ki values are 0.1 and 0.2µM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.
- Chemical Name: 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
- Formula: C12H21NO8S
- CAS Number: 97240-79-4
- Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
- Purity: >99