Torc1 Mouse anti-Human, Mouse, Non-human primate, Rat, Clone: 2D4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524872
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.Acts as a coactivator, in the SIK/TORC signaling pathway,being active when dephosphorylated and acts independently of CREB1 ft.Ser-133 ft. phosphorylation.Enhances the interaction of CREB1 with TAF4.Regulates the expression of specific CREB-activated genes such as the steroidogenic gene,StAR.Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintece at the Schaffer collateral-CA1 synapses.May be required for dendritic growth of developing cortical neurons.
|Recombit full length Human TORC1.|
|Antigen affinity chromatography|
|Human, Mouse, Non-human primate, Rat|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.4|
|Q157S1, Q68ED7, Q6UUV9|
|KIAA0616; CREB regulated transcription coactivator 1; CREB-regulated transcription coactivator 1; CRTC1; CRTC1; FLJ14027; KIAA0616; MECT 1; Mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; TORC-1; TORC1; Transducer of CREB protein 1; Transducer of regulated cAMP response element binding protein 1; Transducer of regulated cAMP response element-binding protein (CREB) 1; Transducer of regulated cAMP response element-binding protein 1; WAMTP1; MECT1; TORC1; TORC-1; WAMTP1.|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|23373, 382056, 684527|
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