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Torc1 Mouse anti-Human, Mouse, Non-human primate, Rat, Clone: 2D4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524872

Catalog No. PIMA524872


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Description

Description

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.Acts as a coactivator, in the SIK/TORC signaling pathway,being active when dephosphorylated and acts independently of CREB1  ft.Ser-133 ft. phosphorylation.Enhances the interaction of CREB1 with TAF4.Regulates the expression of specific CREB-activated genes such as the steroidogenic gene,StAR.Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintece at the Schaffer collateral-CA1 synapses.May be required for dendritic growth of developing cortical neurons.
Specifications

Specifications

Torc1
Monoclonal
Unconjugated
CRTC1
Liquid
CRTC1
Recombit full length Human TORC1.
Antigen affinity chromatography
RUO
Antibody
Monoclonal
Human, Mouse, Non-human primate, Rat
Western Blot
2D4
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q157S1, Q68ED7, Q6UUV9
KIAA0616; CREB regulated transcription coactivator 1; CREB-regulated transcription coactivator 1; CRTC1; CRTC1; FLJ14027; KIAA0616; MECT 1; Mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; TORC-1; TORC1; Transducer of CREB protein 1; Transducer of regulated cAMP response element binding protein 1; Transducer of regulated cAMP response element-binding protein (CREB) 1; Transducer of regulated cAMP response element-binding protein 1; WAMTP1; MECT1; TORC1; TORC-1; WAMTP1.
Mouse
IgM
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
23373, 382056, 684527
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