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Torc1 Mouse anti-Human, Clone:, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524762

Catalog No. PIMA524762

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1) functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein. Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.
Specifications

Specifications

Torc1
Monoclonal
0.1M tris glycine with 150nM NaCl, 50% glycerol and 0.09% sodium azide
Q6UUV9
KIAA0616;CREB regulated transcription coactivator 1;CREB-regulated transcription coactivator 1;CRTC1;CRTC1_HUMAN;FLJ14027;KIAA0616;MECT 1;Mucoepidermoid carcinoma translocated 1;Mucoepidermoid carcinoma translocated protein 1;TORC-1;TORC1;Transducer of CREB protein 1;Transducer of regulated cAMP response element binding protein 1; Transducer of regulated cAMP response element-binding protein (CREB) 1;Transducer of regulated cAMP response element-binding protein 1;WAMTP1.
Mouse
IgG2b
100 μL
-20°C
Primary
23373
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Unconjugated
CRTC1
Liquid
CRTC1
Human CRTC1 recombit protein
Purified
RUO
Antibody
Monoclonal
Human
Documents
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