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FAIM3 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550408

Catalog No. PA550408


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Description

Description

The antibody detects endogenous levels of total Toso protein.

Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.
Specifications

Specifications

FAIM3
Polyclonal
Unconjugated
FCMR
Liquid
FCMR
Fusion protein corresponding to a region derived from internal residues of human Fas apoptotic inhibitory molecule 3
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
0.8 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
O60667
FAIM3, TOSO
Rabbit
IgG
100 μL
-20°C
Primary
9214
Documents
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