TP73 Mouse anti-Human, Clone: 38C674.2, Abnova™
Mouse monoclonal antibody raised against human TP73.
Manufacturer: Abnova Corporation MAB12972
This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq]Sequence: LYVGDPARHLAT
|Mouse monoclonal antibody raised against human TP73.|
|In PBS (0.05% BSA, 0.05% sodium azide).|
|Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|ChIP assay, Immunohistochemistry (PFA fixed), Western Blot|
|ChIP Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL) Western Blot (1-3 ug/mL) The optimal working dilution should be determined by the end user.|
|A synthetic peptide corresponding to amino acids 2-13 of human TP73.|
|Protein G purification|
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