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TPPU, >98%, Tocris Bioscience™

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Quantity:
50 mg
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C16H20F3N3O3
Soluble to 100mM in DMSO and to 50mM in ethanol
1222780-33-7
N-[1-(1-Oxopropyl)-4-piperidinyl]-N′-[4-(trifluoromethoxy)phenyl]urea
>98%
This item is not returnable. View return policy
C16H20F3N3O3
Soluble to 100mM in DMSO and to 50mM in ethanol
1222780-33-7
N-[1-(1-Oxopropyl)-4-piperidinyl]-N′-[4-(trifluoromethoxy)phenyl]urea
>98%

Potent soluble epoxide hydrolase inhibitor; orally bioavailable and brain penetrant

Potent soluble epoxide hydrolase (sEH) inhibitor (IC50 values are 1.1 and 2.1 nM for murine and human receptor, respectively). Inhibits MAPK and NF-κB signaling, as well as reducing ER stress and cell death in models of pancreatitis. Exhibits antidepressant effects in a social defeat stress model. Orally bioavailable and brain penetrant.
Molecular Formula C16H20F3N3O3
Quantity 50 mg
Synonym tppu, 1-1-propanoylpiperidin-4-yl-3-4-trifluoromethoxy phenyl urea, 1-1-propionylpiperidin-4-yl-3-4-trifluoromethoxy phenyl urea, n-1-1-oxopropyl-4-piperidinyl-n'-4-trifluoromethoxy phenyl urea, 2rv
InChI Key AAJMQTLFRTZCJK-UHFFFAOYSA-N
SMILES CCC(=O)N1CCC(CC1)NC(=O)NC2=CC=C(C=C2)OC(F)(F)F
IUPAC Name 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea
Molecular Weight (g/mol) 359.349
PubChem CID 44142782
Formula Weight 359.34

Recommended Storage : Store at +4°C