TRACP/PAP/ACP5 Antibody (rACP5/1070), Alexa Fluor™ 647, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP275780AF647

Catalog No. NB009162

Description

TRACP/PAP/ACP5 Monoclonal specifically detects TRACP/PAP/ACP5 in Human, Mouse, Rat samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: TRACP/PAP/ACP5
• Classification: Monoclonal
• Conjugate: Alexa Fluor 647
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Symbols: ACP5
• Immunogen: Recombinant full-length human TRACP/PAP/ACP5 protein (Uniprot: P13686)
• Quantity: 0.1 mL
• Research Discipline: Protein Phosphatase
• Test Specificity: It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This monoclonal antibody reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis.Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gauchers Disease, HIV-induc
• Content And Storage: Store at 4°C in the dark.

• Applications: Immunohistochemistry, Immunohistochemistry (Paraffin)
• Clone: rACP5/1070
• Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin
• Gene Alias: HPAP, TRACP5a, TRACP5b, TRAP, TrATPase
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Isotype: IgG1 κ