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TRAF5 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550278

Catalog No. PA550278


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Description

Description

The antibody detects endogenous levels of total TRAF5 protein.

Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6) (1-4). TRAF5 is a 558-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-beta receptor. Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymhocyte activation (5).
Specifications

Specifications

TRAF5
Polyclonal
Unconjugated
TRAF5
Liquid
TRAF5
Fusion protein corresponding to a region derived from internal residues of human TNF receptor-associated factor 5
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
0.9 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
O00463
MGC:39780, RNF84
Rabbit
IgG
100 μL
-20°C
Primary
7188
Documents
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