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TRAILR2/DR5/CD262 Rabbit anti-Human, Polyclonal, Bioss
Rabbit Polyclonal Antibody
Manufacturer: Bioss BS1696R
Description
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.Specifications
TRAILR2/DR5/CD262 | |
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
Unconjugated | |
TNFRSF10B | |
Liquid | |
Rabbit | |
IgG | |
100 μL | |
-20°C | |
Primary | |
8795 |
TNFRSF10B | |
1 μg/mL | |
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH | |
O14763 | |
apoptosis inducing protein TRICK2A/2B; apoptosis inducing receptor TRAIL-R2; CD262; cytotoxic TRAIL receptor-2; death domain containing receptor for TRAIL/Apo-2L; Death receptor 5; DR5; Fas-like protein; Killer; KILLER/DR5; KILLER/DR5 TRAIL death-inducing receptor; Ly98; MK; p53-regulated DNA damage-inducible cell death receptor(killer); sCD262; soluble CD262; TNF receptor superfamily member 10b; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TRAIL receptor 2; TRAILR2; TRAIL-R2; TRICK2; TRICK2A; TRICK2B; TRICKB; Tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor-like protein ZTNFR9; UNQ160/PRO186; ZTNFR9 | |
KLH conjugated synthetic peptide derived from mouse DR5. | |
Protein A | |
RUO | |
Antibody | |
Polyclonal | |
Human |
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