TRIP Mouse anti-Human, Clone: OTI2D4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526366
DescriptionE3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting ft.Lys-48 ft.-linked polyubiquitination of TNK1 leading to its proteasomal degradation (PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase (PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of ft.Lys-63 ft.-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is controversial (PubMed:26595769).
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|RING finger protein 206; TRAF-interacting protein; TRAIP; RNF206; TRIP|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 67-313 of TRAIP produced in E.coli|
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