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TRIP Mouse anti-Human, Clone: OTI2D4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526366

Catalog No. PIMA526366


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Description

Description

E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting  ft.Lys-48 ft.-linked polyubiquitination of TNK1 leading to its proteasomal degradation (PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase (PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of  ft.Lys-63 ft.-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is controversial (PubMed:26595769).
Specifications

Specifications

TRIP
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9BWF2
RING finger protein 206; TRAF-interacting protein; TRAIP; RNF206; TRIP
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
10293
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
OTI2D4
Unconjugated
TRAIP
Liquid
TRAIP
Human recombit protein fragment corresponding to amino acids 67-313 of TRAIP produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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