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Tocris™ TRAM 39

Potent KCa3.1 blocker

Manufacturer:  Tocris™ 4952/10

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Catalog No. 49-521-0

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For Research Use Only



Potent intermediate conductance Ca2+-activated K+ channel (KCa3.1) blocker (Kd = 60nM). Has no effect on cytochrome p450 activity. Inhibits I-EBIO-stimulated increases in rat artery membrane potential ex vivo. Also diminishes LPS-induced cryptidin (mammalian α-defensin) release from paneth cells in vitro.
  • Chemical Name: 2-Chloro-α,α-diphenylbenzeneacetonitrile
  • Formula: C20H14ClN
  • CAS Number: 197525-99-8
  • Solubility: Soluble to 50mM in DMSO
  • Purity: >99
Description & Specifications


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