Potent intermediate conductance Ca2+-activated K+ channel (KCa3.1) blocker (Kd = 60nM). Has no effect on cytochrome p450 activity. Inhibits I-EBIO-stimulated increases in rat artery membrane potential ex vivo. Also diminishes LPS-induced cryptidin (mammalian α-defensin) release from paneth cells in vitro.
Chemical Name: 2-Chloro-α,α-diphenylbenzeneacetonitrile
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