Tocris TRAM 39
Potent KCa3.1 blocker
Manufacturer: Tocris 4952/10
DescriptionPotent intermediate conductance Ca2+-activated K+ channel (KCa3.1) blocker (Kd = 60nM). Has no effect on cytochrome p450 activity. Inhibits I-EBIO-stimulated increases in rat artery membrane potential ex vivo. Also diminishes LPS-induced cryptidin (mammalian α-defensin) release from paneth cells in vitro.
- Chemical Name: 2-Chloro-α,α-diphenylbenzeneacetonitrile
- Formula: C20H14ClN
- CAS Number: 197525-99-8
- Solubility: Soluble to 50mM in DMSO
- Purity: >99
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