Tocris™ trans-ISRIB

Integrated stress response (ISR) inhibitor

Manufacturer: Tocris™ 5284/10

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Catalog No. 52-841-0

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For Research Use Only


    Specifications

    Product Type trans-ISRIB
    Inhibitors trans-ISRIB
    Purity >99
    Molecular Weight 451.34
    Quantity 10mg

    Integrated stress response (ISR) inhibitor; reverses the effects of eIF2α phosphorylation (IC50 = 5nM) and restores cell translation capacity. Acts downstream of PERK, targeting interactions between eIF2α kinases and elF2B. Blocks ATF4 production without altering the IRE1 or ATF6 responses in vitro. Displays memory enhancement in hippocampus-dependent spatial and fear-associated learning in rodents. Brain penetrant.

    • Chemical Name: N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]
    • Formula: C22H24Cl2N2O4
    • CAS Number: 1597403-47-8
    • Solubility: Soluble to 10mM in DMSO with gentle warming
    • Purity: >99

  • Description & Specifications

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