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TREX1 Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 248761AP

Catalog No. 50-173-4590


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Description

Description

Trex1 (ATRIP) is the major human 3 ft. to 5 ft. exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3 ft. to 5 ft. exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.
Specifications

Specifications

TREX1
0.35 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q9NSU2
3 5 exonuclease TREX1, AGS1, AGS5, CRV, DNase III, DRN3, HERNS, TREX1
Rabbit
IgG
150 μL
-20°C
Primary
11277
Immunoprecipitation, Western Blot
Unconjugated
TREX1
Liquid
TREX1
TREX1 Fusion Protein Ag18325
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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