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TRIB1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550851

Catalog No. PA550851


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Description

Description

The antibody detects endogenous levels of total TRIB1 protein.

TRIB1 antibody, also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1.
Specifications

Specifications

TRIB1
Polyclonal
Unconjugated
TRIB1
Liquid
TRIB1
Synthetic peptide corresponding to residues near the C terminal of human tribbles pseudokinase 1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin)
1.4 mg/mL
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Q96RU8, Q8K4K4
C8FW, GIG2, TRB1
Rabbit
IgG
100 μL
-20°C
Primary
10221, 211770
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