TRIB1 Mouse anti-Human, Clone: OTI8C8, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526721
DescriptionTRIB1 antibody, also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|C8FW, GIG2, SKIP1, TRB1, G-protein-coupled receptor induced protein, G-protein-coupled receptor-induced gene 2 protein, G-protein-coupled receptor-induced protein 2, GIG-2, TRB-1, phosphoprotein regulated by mitogenic pathways, tribbles homolog 1, tribbles-like protein 1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of TRIB1 produced in HEK293T cell|
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