TRIB2 Mouse anti-Human, Clone: 1D11, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524548
Peptide Sequence: MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE TPNLSHCVSC IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFDISCYQES LAPCFCLSAH SNINQITEII LGETKAYVFF ERSYGDMHSF VRTCKKLREE EAARLFYQIA SAVAHCHDGG LVLRDLKLRK FIFKDEERTR VKLESLEDAY ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL GVMLYTMLVG RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ EILDHPWFST DFSVSNSAYG AKEVSDQLVP DVNMEENLDP FFNThis gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
|TRIB2 (AAH02637, 1 a.a. ∽ 343 a.a) full-length recombit protein with GST tag. MW of the GST tag alone is 26 KDa.|
|ELISA, Immunoprecipitation, Western Blot|
|PBS with no preservative; pH 7.4|
|Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809), TRB2|
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