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TRIB2 Mouse anti-Human, Clone: 1D11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524548

Catalog No. PIMA524548


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Description

Description

Peptide Sequence: MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE TPNLSHCVSC IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFDISCYQES LAPCFCLSAH SNINQITEII LGETKAYVFF ERSYGDMHSF VRTCKKLREE EAARLFYQIA SAVAHCHDGG LVLRDLKLRK FIFKDEERTR VKLESLEDAY ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL GVMLYTMLVG RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ EILDHPWFST DFSVSNSAYG AKEVSDQLVP DVNMEENLDP FFN

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
Specifications

Specifications

TRIB2
Monoclonal
Unconjugated
TRIB2
Liquid
TRIB2
TRIB2 (AAH02637, 1 a.a. ∽ 343 a.a) full-length recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
Protein A
RUO
Antibody
Monoclonal
Human
ELISA, Immunoprecipitation, Western Blot
1D11
PBS with no preservative; pH 7.4
Q92519
Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809), TRB2
Mouse
IgG2a, kappa
100 μg
-20° C
Primary
28951
Documents
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