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TRIB2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA551306

Catalog No. PA551306


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Description

Description

The antibody detects endogenous levels of total TRIB2 protein.

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
Specifications

Specifications

TRIB2
Polyclonal
Unconjugated
TRIB2
Liquid
TRIB2
Full length fusion protein of human TRIB2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1.8 mg/mL
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Q92519
TRB2
Rabbit
IgG
100 μL
-20°C
Primary
28951
Documents
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