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TRIB2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549660

Catalog No. PA549660

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Predicted to react with bovine and mouse based on sequence homology.

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
Specifications

Specifications

TRIB2
Polyclonal
Unconjugated
TRIB2
Liquid
TRIB2
KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TRIB2.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human, Mouse
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
2 mg/mL
PBS with 0.09% sodium azide
Q92519, Q8K4K3
Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809)
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
217410, 28951
Documents
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